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Sam Solomon, W. D.
- A Validated Reversed Phase HPLC-Method for the Determination of Aceclofenac and Tizanidine in Tablets
Authors
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 2, No 1 (2010), Pagination: 84-94Abstract
A new simple, accurate, precise and reproducible Reverse Phase-High Performance Liquid Chromatographic method has been developed for the simultaneous estimation of Aceclofenac and Tizanidine in tablet dosage forms using C18 column (Ineretsil, 250 x 4.6 mm, 5 μm) in isocratic mode. The mobile phase consisted of acetonitrile, methanol and 20 mM phosphate buffer adjusted to pH 3.5 in ratio of (40:30:30 v/v) with Ultraviolet-Visible detection at 230 nm. The method was linear over the concentration range for aceclofenac120-280 μg/ml and for tizanidine 2-40 μg/ml. The recoveries of Tizanidine and Aceclofenac were found to be in the range of 99.45-100.61% and 99.56-101.32% respectively. The validation of method was carried out using International Conference on Harmonization-guidelines. The described High Performance Liquid Chromatographic method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form.Keywords
Simultaneous Estimation, RP - HPLC, Aceclofenac, Tizanidine, ICH Guidelines.- Derivatized HPTLC Method for Simultaneous Estimation of Glucosamine and Ibuprofen in Tablets
Authors
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 2, No 2 (2010), Pagination: 156-162Abstract
A selective, precise and derivatized HPTLC method has been developed for the simultaneous estimation of Glucosamine and Ibuprofen in tablet formulation. In this method standard and sample solutions of Glucosamine and Ibuprofen were applied on pre-coated silica gel 60F254 TLC plate, and developed using Propanol-Ethyl acetate-Ammonia-Water (4: 3: 2: 1 v/v), as mobile phase and derivatized using Iodine vapor. The drugs on the plate were scanned at 254 nm. The dynamic linearity range was 5-25 μg/spot for Glucosamine and 2-10 μg/spot for Ibuprofen. The method was validated for precision, recovery and reproducibility.Keywords
Simultaneous Estimation, HPTLC, Glucosamine and Ibuprofen.- Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form
Authors
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 3 (2011), Pagination: 50-52Abstract
Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm ((λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent.The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin.The results of analysis have been validated statically and by recover studies and were found satisfactory.Keywords
Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.- Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form
Authors
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 2 (2011), Pagination: 36-38Abstract
Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous estimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5-25 μg/ml for Cefixime and 2-10 μg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.Keywords
Cefixime, Ofloxacin, Simultaneous Equations, Absorbance Ratio Method.- Simultaneous Estimation of Amoxycillin Trihdrate and Dicloxacillin Sodium in Formulation by UV-Spectroscopy
Authors
1 Department of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore - 641402, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 241-243Abstract
A simple UV- Spectrophotometric method has been developed for simultaneous estimation of Amoxycillin Trihydrate and Dicloxacillin Sodium from Pharmaceutical dosage forms. Methanol: water (1:1) was used as solvent. The method involves the measurement of absorbance at two wavelengths 290 nm (λmax for Amoxycillin) and 274nm (λmax for Dicloxacillin). The linearity lies between 2-10 μg/ml for Amoxycillin and10-50 μg/ml for Dicloxacillin. The accuracy and precision of the methods were determined and validated statiscally. The method showed good reproducibility and recovered with %RSD less than 2. The method are found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of simultaneous estimation of Amoxycilin and Dicloxacillin in bulk and combined dosage form.
Keywords
Simultaneous, UV-Spectrophotometric, Amoxycilin, Dicloxacillin.- Derivatized HPTLC Method for Simultaneous Estimation of Glucosamine, Vitamin C and Vitamin E in Tablets
Authors
1 Dept. of Pharmaceutical Analysis, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 329-331Abstract
An accurate, precise and derivatized HPTLC method has been developed for the simultaneous estimation of Glucosamine, Vitamin C and Vitamin E in tablet formulation. In this method standard and sample solutions of Glucosamine, Vitamin C and Vitamin E were applied on pre-coated silica gel 60F254 TLC plate, and developed using ethanol:Acetic acid (9:1 v/v), as mobile phase and derivatized using Iodine vapor. The drugs on the plate were scanned at 500 nm. The dynamic linearity range was 20-100 μg/spot for Glucosamine, 2-10 μg/spot for Vitamin C and 0.2-1 μg/spot for Vitamin E. The method was validated for precision, accuracy and reproducibility.Keywords
Simultaneous Estimation, HPTLC, Glucosamine, Vitamin C and Vitamin E.- Computer Aided Docking Studies on Antiviral Drugs for Bird Flu
Authors
1 Dept. of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, (T.N.), IN